Category Archives: Health Benefits

Exercise to Lower Your Risk of Dying (Prematurely) with Type 1 Diabetes

Bob Stewart Jumping (crop)Much of the research on length of life for individuals living with type 1 diabetes is pessimist, which makes a new study released recently a breath of fresh air. Data were collected for the ongoing nationwide, multicenter, Finnish Diabetic Nephropathy (FinnDiane) Study that tracked the death rate of 2,639 study participants for an average of 11.4 ± 3.5 years (1).

In this study, participants’ leisure time physical activity was reported via a self-report questionnaire. Importantly, their physical activity and its intensity, duration, and frequency were examined related to dying from all causes and from cardiovascular events; some of these adults with type 1 diabetes already had diabetic kidney disease.

The researchers also looked at potentially confounding factors like sex, how long people had been diagnosed with type 1 diabetes and how old they were when they got it, as well as physical measures like their systolic blood pressure, triglycerides (blood fats), BMI (body mass index), and HbA1c (a measure of overall blood glucose control over two to three months).

The conclusions of this study came as no surprise to me: exercise is associated with a lower risk of premature death from cardiovascular or any other cause in adults with type 1 diabetes. Overall, 270 people died during the follow-up period, 127 of whom had kidney disease. Only exercise intensity was associated with cardiovascular mortality, with intense activity being best for preventing early death from cardiovascular events. Both how much total physical activity they got and how frequently they exercised were associated with a lower risk of dying from any cause. Prior studies have shown that exercise frequency may also matter in preventing such events, with a higher frequency of physical activity lowering the risk (2).

People with type 2 diabetes have already been shown to have a lower risk of premature death when they are physically active (3); this is also true for the adult population in general (4; 5). However, not as many studies have looked specifically at the association between physical activity and lower mortality risk in adults with type 1 diabetes. Type 1 diabetes has previously been associated with a shorter lifespan in many adults with it, particularly related to endothelial dysfunction and cardiovascular disease (6).

Earlier studies, such as the DCCT, have shown that keeping blood glucose levels in a more normal range can help lower the risk of diabetes-related complications in people with type 1 diabetes. Most deaths in this population are related to either cardiovascular events or kidney failure. Exercise has an innate ability to lower oxidative stress, which has been implicated in the development of many complications, as well as improve endothelial function (6). While regular physical activity is associated with a lower risk of early death in adults with and without type 2 diabetes, this study is one of the first to examine this association in type 1 diabetes.

While the exact amount of exercise needed to lower the risk of cardiovascular events is unknown and not determined by this study, doing any activity is arguably better than remaining sedentary. As in people without diabetes, intense activity likely is even more cardioprotective than moderate or light activity.

However, the exercise in this study was self-reported and only collected at the start of the study, making it is hard to draw definitive conclusions about how much exercise people need to do and how intense it needs to be to reduce the risk of dying.

In conclusion, as confirmed by this latest study, being physically active on a regular basis is critical to living long and well with type 1 diabetes. Remaining sedentary is far worse for your health and your longevity, so go get active!

                                                                                                                                                           

References cited:

  1. Tikkanen-Dolenc H, Waden J, Forsblom C, Harjutsalo V, Thorn LM, Saraheimo M, Elonen N, Tikkanen HO, Groop PH: Physical Activity Reduces Risk of Premature Mortality in Patients With Type 1 Diabetes With and Without Kidney Disease. Diabetes Care 2017;16:dc17-0615
  2. Tikkanen-Dolenc H, Waden J, Forsblom C, Harjutsalo V, Thorn LM, Saraheimo M, Elonen N, Rosengard-Barlund M, Gordin D, Tikkanen HO, Groop PH: Frequent and intensive physical activity reduces risk of cardiovascular events in type 1 diabetes. Diabetologia 2017;60:574-580. doi: 510.1007/s00125-00016-04189-00128. Epub 02016 Dec 00124.
  3. Loprinzi PD, Sng E: The effects of objectively measured sedentary behavior on all-cause mortality in a national sample of adults with diabetes. Prev Med 2016;86:55-57
  4. Biswas A, Oh PI, Faulkner GE, Bajaj RR, Silver MA, Mitchell MS, Alter DA: Sedentary time and its association with risk for disease incidence, mortality, and hospitalization in adults: a systematic review and meta-analysis. Ann Intern Med 2015;162:123-132
  5. Chau JY, Grunseit AC, Chey T, Stamatakis E, Brown WJ, Matthews CE, Bauman AE, van der Ploeg HP: Daily sitting time and all-cause mortality: a meta-analysis. PLoS One 2013;8:e80000
  6. Bertoluci MC, Ce GV, da Silva AM, Wainstein MV, Boff W, Punales M: Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes. World J Diabetes 2015;6:679-692
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Are My Joint Issues Due to Being Active, Normal Aging, or Diabetes?

Sheri DHHS 30th climbing side viewLiving with diabetes often leads me to wonder if what I’m experiencing—particularly when it’s an irritated joint or an overuse injury—is a consequence of being a regularly physically active person, getting older, or having diabetes, or some combination of those. Which one of these is causing my joint issues? Is it possible to know? I will attempt to answer these questions based on my deeper dive into the published research.

Personally, I have managed to avoid most overuse injuries (such as joint tendinitis) related to physical activity by engaging in cross-training and doing different activities on varying days, and this strategy worked well for me for over 25 years. Of late, though, I have started experiencing chronic overuse injuries (or sometimes just short-term joint irritation) that appear to arise not from most of my usual activities, but more from unusual ones—such as hand-scrubbing my house to get it ready to sell (dominant shoulder joint irritation), tamping down my front yard with a hand compactor (alternate shoulder joint pain that lasted for several years and recurs occasionally), driving a car for several hours in traffic after not driving far often (ankle joint tendinitis of some sort that took months to fully resolve), and random aches and pains in joints that come and go on any given day and may only last a few days at most.

Yes, I’m getting older (aren’t we all?), having successfully passed the half-century mark. I’ve also been living with type 1 diabetes for nearly 50 years (diagnosed at age four in 1968). My A1Cs are in recommended ranges (usually near 6.0%) and have been good ever since I got my first blood glucose meter in 1986 (after going 18 years with nothing but urine testing). I still have blood glucose fluctuations while trying to manage food, exercise, stress, occasional lack of sleep, hormonal variations, illness, and other usual factors that impact my daily levels. So, are my own occasional joint issues the result of being an active person (exercising daily for decades), normal aging, or long-standing diabetes (despite being in relatively good control for the past 30+ years)?

Are overuse injuries more likely to occur due to diabetes or aging? Overuse injuries from participation in athletic endeavors (even just walking) are more common in people with diabetes, likely due to changes in joint structures when exposed to hyperglycemia over time (1). But aging also increases the incidence of overuse injuries when exercisers are older (2). For instance, in one study 70% of the injuries in older exercisers (over 60 years) were overuse injuries, but accounted for only 41% of injuries in younger adults (early 20s).

Is it due to inflammation related to aging or to diabetes? Aging lab rats have overuse activity changes to the structure of their tendons related to inflammation that may make them more prone to injury (3), but when it comes to humans, the research is unclear whether inflammation is involved (4). In one review (5), “prolonged systemic, low-grade inflammation and impaired insulin sensitivity act as a risk factor for a failed healing response after an acute tendon insult and predispose to the development of chronic overuse tendinopathies.” Perhaps, then, in people with diabetes, joint structures do not respond as well to or repair as quickly after activities (6).

Others have argued that low-level, systemic inflammation is not involved in changes to tendons that may lead to injury (4). People with diabetes have some structural joint changes that may or may not be related to diabetes duration or type, although poorer blood glucose management has been associated with higher levels of systemic inflammation (1). Fit, active adults with type 1 diabetes with good blood glucose control exhibit more inflammatory markers in response to exercise, but appear to recover normally (7). If someone has had “good” control for many years, does that lower the chance that their overuse injuries are diabetes-related? I’m quickly raising more questions than I can answer!

Other joint issues like frozen shoulder, carpal tunnel syndrome, and trigger finger are more common in people with diabetes, and structural changes to tendons may occur in people with diabetes (8). On the other hand, my non-diabetic, aging (mid-50s), reasonably active neighbor has had two frozen shoulders in recent years that clearly have nothing to do with diabetes or blood glucose management. I’ve also known people with diabetes who are active that develop a frozen shoulder, but others who get this condition are sedentary, suggesting that such joint issues are not consistently related to diabetes or habitual physical activity.

In short, if you are reading this in hopes of finding out whether joint pains and overuse injuries are more related to being active, aging, or diabetes, you are about to be sorely disappointed because I am unable to determine that based on available research. That said, it is likely that getting older (and not springing back as quickly) contributes to the rise in overuse injuries with aging, but that just means that everyone will have to find ways to be active that do not aggravate any existing issues. The best policy still is to vary your activities, try not to overdo or act like you’re still twenty, and rest appropriately and take time off when necessary to recover from injuries. Given we’re all aging and a significant number of us will be developing diabetes in our later years (if we don’t have it already), it is a topic ripe with possibility for future research.

                                                                                                                                                           

References cited:

  1. Abate M, Schiavone C, Salini V, Andia I: Management of limited joint mobility in diabetic patients. Diabetes Metab Syndr Obes 2013;6:197-207
  2. Kannus P, Niittymaki S, Jarvinen M, Lehto M: Sports injuries in elderly athletes: a three-year prospective, controlled study. Age Ageing 1989;18:263-270.
  3. Kietrys DM, Barr-Gillespie AE, Amin M, Wade CK, Popoff SN, Barbe MF: Aging contributes to inflammation in upper extremity tendons and declines in forelimb agility in a rat model of upper extremity overuse. PLoS One 2012;7:e46954. doi: 46910.41371/journal.pone.0046954.
  4. Kjaer M, Bayer ML, Eliasson P, Heinemeier KM: What is the impact of inflammation on the critical interplay between mechanical signaling and biochemical changes in tendon matrix? 1985) 2013;115:879-883. doi: 810.1152/japplphysiol.00120.02013.
  5. Del Buono A, Battery L, Denaro V, Maccauro G, Maffulli N: Tendinopathy and inflammation: some truths. Int J Immunopathol Pharmacol 2011;24:45-50.
  6. Battery L, Maffulli N: Inflammation in overuse tendon injuries. Sports Med Arthrosc 2011;19:213-217. doi: 210.1097/JSA.1090b1013e31820e31826a31892.
  7. West DJ, Campbell MD, Gonzalez JT, Walker M, Stevenson EJ, Ahmed FW, Wijaya S, Shaw JA, Weaver JU: The inflammation, vascular repair and injury responses to exercise in fit males with and without Type 1 diabetes: an observational study. Cardiovasc Diabetol 2015;14:71
  8. de Jonge S, Rozenberg R, Vieyra B, Stam HJ, Aanstoot HJ, Weinans H, van Schie HT, Praet SF: Achilles tendons in people with type 2 diabetes show mildly compromised structure: an ultrasound tissue characterisation study. Br J Sports Med 2015;49:995-999. doi: 910.1136/bjsports-2014-093696.

Is Sitting the New Smoking?

Sitting

Make no mistake: sitting less time overall is a good idea for myriad health reasons, but is sitting as bad for you as some would suggest? Is it really the new smoking? In 2017 alone, a slew of new research studies has looked at various health detriments associated with prolonged sitting, even in adults who exercise regularly.

For adults with type 2 diabetes, bouts of either light walking or simple resistance activities benefit not only their glycemic responses to meals (1; 2), but also markers of cardiovascular risk. Both types of interrupting activities are associated with reductions in inflammatory lipids, increases in antioxidant capacity of other lipids, and changes in platelet activation (3).

What is good for one may not be as beneficial for all, though. For example, in adults with low levels of frailty, sedentary time is not predictive of mortality, regardless of physical activity level (4). Sitting more if you are already frail likely just increases frailty and mortality risk, which is not surprising. Along the same lines, being less fit matters in how you respond to breaking up sedentary time. Middle-aged adults with low levels of cardiorespiratory fitness gained the most metabolic benefit from breaking prolonged sitting with regular bouts of light walking, which included five minutes of light walking every 30 minutes over a 7-hour research period (5). If you’re already very fit, adding in some light walking breaks during the day is not going to have as much of an effect—again not surprising.

For in adolescents in school, reducing their sitting time (both in total time and length of bouts) has been shown to improve their blood lipid profiles and cognitive function. A “typical” day (65% of the time spent sitting with two sitting bouts >20 minutes) was compared with a simulated “reduced sitting” day (sitting 50% less with no bouts >20 minutes (6). Can teens stand to improve their health this week? Again, it cannot hurt to break up sedentary time, so why not do it? More recess breaks for teens would be good—and for everyone else for that matter.

All is not lost for people with limited mobility or no ability to engage in weight-bearing activities. Including short bouts of arm ergometry (five minutes of upper body work only every 30 minutes) during prolonged sitting attenuates postprandial glycemia (following two separate meals) when done by obese individuals at high risk of developing type 2 diabetes, even though they remain seated (7). People who cannot walk or stand can, therefore, break up their sedentary time in other ways that can also be metabolically beneficial.

As for other health benefits, breaking up sedentary time is associated with a lower risk of certain types of cancer. In a recent meta-analysis, prolonged television viewing, occupational sitting time, and total sitting time were all associated with increased risks of colorectal cancer in adults (8), which is the most common type after breast/prostate and lung cancers. That study reported a dose-response effect as well, suggesting that both prolonged total sitting time and greater total daily sitting time (2 hours) were associated with a significantly higher risk of colorectal cancer.

In summary, even just the most recent evidence is convincing enough that prolonged sitting is bad for you, and many more studies published similar results in prior years. Is sitting as bad as smoking, though? That remains to be proven. However, you really cannot argue with a recent international consensus statement on sedentary time in older people (9). It states, “Sedentary time is a modifiable determinant of poor health, and in older adults, reducing sedentary time may be an important first step in adopting and maintaining a more active lifestyle.” In fact, the best advice may simply be to consider the whole spectrum of physical activity, from sedentary behavior through to structured exercise (10). Putting yourself anywhere onto that spectrum is definitely better than sitting through the rest of your (shortened) life.

                                                                                                                                                            References cited:

 

  1. Larsen RN, Dempsey PC, Dillon F, Grace M, Kingwell BA, Owen N, Dunstan DW: Does the type of activity “break” from prolonged sitting differentially impact on postprandial blood glucose reductions? An exploratory analysis. Appl Physiol Nutr Metab 2017;42:897-900. doi: 810.1139/apnm-2016-0642. Epub 2017 Mar 1124.
  2. Dempsey PC, Larsen RN, Sethi P, Sacre JW, Straznicky NE, Cohen ND, Cerin E, Lambert GW, Owen N, Kingwell BA, Dunstan DW: Benefits for type 2 diabetes of interrupting prolonged sitting with brief bouts of light walking or simple resistance activities. Diabetes Care 2016;39:964-972
  3. Grace MS, Dempsey PC, Sethi P, Mundra PA, Mellett NA, Weir JM, Owen N, Dunstan DW, Meikle PJ, Kingwell BA: Breaking Up Prolonged Sitting Alters the Postprandial Plasma Lipidomic Profile of Adults With Type 2 Diabetes. J Clin Endocrinol Metab 2017;102:1991-1999. doi: 1910.1210/jc.2016-3926.
  4. Theou O, Blodgett JM, Godin J, Rockwood K: Association between sedentary time and mortality across levels of frailty. CMAJ 2017;189:E1056-E1064. doi: 1010.1503/cmaj.161034.
  5. McCarthy M, Edwardson CL, Davies MJ, Henson J, Bodicoat DH, Khunti K, Dunstan DW, King JA, Yates T: Fitness Moderates Glycemic Responses to Sitting and Light Activity Breaks. Med Sci Sports Exerc 2017;8:0000000000001338
  6. Penning A, Okely AD, Trost SG, Salmon J, Cliff DP, Batterham M, Howard S, Parrish AM: Acute effects of reducing sitting time in adolescents: a randomized cross-over study. BMC Public Health 2017;17:657. doi: 610.1186/s12889-12017-14660-12886.
  7. McCarthy M, Edwardson CL, Davies MJ, Henson J, Rowlands A, King JA, Bodicoat DH, Khunti K, Yates T: Breaking up sedentary time with seated upper body activity can regulate metabolic health in obese high-risk adults: A randomized crossover trial. Diabetes Obes Metab 2017;23:13016
  8. Ma P, Yao Y, Sun W, Dai S, Zhou C: Daily sedentary time and its association with risk for colorectal cancer in adults: A dose-response meta-analysis of prospective cohort studies. Medicine (Baltimore) 2017;96:e7049. doi: 7010.1097/MD.0000000000007049.
  9. Dogra S, Ashe MC, Biddle SJH, Brown WJ, Buman MP, Chastin S, Gardiner PA, Inoue S, Jefferis BJ, Oka K, Owen N, Sardinha LB, Skelton DA, Sugiyama T, Copeland JL: Sedentary time in older men and women: an international consensus statement and research priorities. Br J Sports Med 2017;19:2016-097209
  10. Dempsey PC, Grace MS, Dunstan DW: Adding exercise or subtracting sitting time for glycaemic control: where do we stand? Diabetologia 2017;60:390-394. doi: 310.1007/s00125-00016-04180-00124. Epub 02016 Dec 00112.

…And Stay Active: My Profile of Success

Sheri exercising pulldown closerI would like to share some of my personal story about why physical activity matters to me and how I have lived successfully with type 1 diabetes for almost 50 years to date. My success with diabetes is undoubtedly related to my decision to be physically active.
The secret to my overall success, both professional and personal, is that I made a conscious choice to live my life by one guiding principle: Live life first, and be diabetic second. In the beginning, I’m not sure it was even a conscious choice (I was only four years old when diagnosed with type 1 diabetes), but rather just an integral part of my personality. I am not one to let obstacles keep me from reaching my goals. Having diabetes has undeniably been one of the greatest challenges to living my life the way I want to, but it has almost never been an insurmountable one.
It’s hard to even imagine life without diabetes when you get it as young as I did. I don’t remember much about being diagnosed other than feeling sluggish and tired all the time. The biggest irony was that my mother had avoided becoming a nurse because she hated needles, but the doctors wouldn’t let me out of the hospital before she learned how to give me shots. She apparently practiced for days shooting water from a syringe into an orange all week. When she gave me my first shot in my arm, she jabbed the needle so hard it rebounded back out. I am told I said, with tears streaming down my face, “Mommy, go practice on the orange some more.”
Diabetes has, in many ways, been a blessing in disguise. It likely had a positive impact on my family’s overall health because our whole family switched to the same diet that was prescribed for me at the time—a balanced diet of carbs, protein, and fat with lots of vegetables, some fruit, and very limited intake of sweets and refined foods. Having diabetes has also been a positive, shaping force in my life when it comes to exercise and physical activity. As such, I have amended my original guiding principle to include, “…and stay active” for that reason: Live life first, be diabetic second, and stay active.
While many people view exercise as a punishment, I fully embrace using diabetes as an excuse to put my workouts first! I started exercising regularly way before it was trendy and known to be good for your health (and blood glucose). I was always active as a kid, playing in the woods, building forts, and just being a tomboy. As a preteen, I began exercising regularly on my own and doing organized sports because being active was the only thing that made me to feel like I had any control over my blood glucose. Way back then no one had blood glucose meters (only inaccurate urine testing), but I could tell being active helped with my blood glucose.
To this day, I still exercise six to seven days a week, and my passion is helping others with all types of diabetes do the same—safely, effectively, and for a lifetime. I vary my daily workouts to keep them fun and to stay injury-free and advise everyone else how to do so. When people ask me how I manage to do all I do, I tell them simply, “I work out.”
Diabetes also led me to an early calling as a healthy lifestyle and diabetes motion expert. When I was about twelve, I spent a week in Kansas with my grandmother, who had what they called “borderline” type 2 diabetes. She was on yet another diet to lose weight, and I decided to help her with dieting while I was there—acting like a personal trainer or fitness coach. I weighed her in every morning, helped her measure out her food (like cottage cheese), and made her jog laps around her backyard. At the start of the week, she agreed to pay me $1 for every pound she lost with my help. She lost eight pounds that week—was I ever a rich kid! Little did I know back then that she likely lost a whole lot less after the first week and gained it all back over time. I just remember her always being about the same body size and shape every time I saw her.
Back then my grandmother was the only other person I knew with diabetes. Later when I was in graduate school working on a degree in exercise physiology, she starting suffering from myriad complications including a heart attack, followed two years later by a major stroke and smaller ones that eventually left her incapacitated. She was bedbound and unable to communicate or feed herself for most her last six years, and she had partial amputations of both of her legs due to chronic ulcers. During one visit, I looked at her and thought, I don’t want to live like that. Consequently, most of my life and career I have focused on how to stay healthy with diabetes and avoid complications. To me, what’s most important is living well while you are alive. That’s why I preach about how important a healthy lifestyle is to maintaining your quality of life (whether you have diabetes or not) and that just living a long time without good health should not be your goal.
You certainly don’t have to get a PhD in exercise physiology like I did to understand the metabolic changes that occur with exercise, but learning why it is so beneficial can be very motivating. You can virtually “erase” overeating mistakes with exercise, and you can keep yourself from getting other health conditions (like heart disease). I’m sure that I am only in excellent health after almost 50 years with type 1 diabetes because of my lifestyle choices—and I want to stay that way until I reach my last day.
As I always say, “What’s the point of living longer if you can’t live well and feel your best every day of your life?” Take my advice and live life first, be diabetic second, and stay as active as you possibly can every day of your healthy (and hopefully long) life.

Staying Active with Aging Joints and Diabetes

Using bandsWithout properly functioning joints, our bodies would be unable to bend, flex, or even move. A joint is wherever two bones come together, held in place by tendons that cross the joint and attach muscles to a bone on the other side and ligaments that attach to bones on both sides of the joint to stabilize it. The ends of the bones are covered with cartilage, a white substance. Specialized cells there called chondrocytes produce large amounts of an extracellular matrix composed of collagen fibers, proteoglycan, elastin fibers, and water. Tendons and ligaments are also made up of primarily of collagen.

Joints can be damaged, however, making movement more difficult or painful. Joint cartilage can be damaged by acute injuries (i.e., ankle sprain, tendon or ligament tears) or overuse (related to repetition of joint movements and wear-and-tear over time). Damage to the thin cartilage layer covering the ends of the bones is not repaired by the body easily or well, mainly because cartilage lacks its own blood supply.

Aging alone can cause you to lose some loss of this articular cartilage layer in knee, hip, and other joints—leading to osteoarthritis and joint pain—but having diabetes also potentially speeds up damage to joints. Although everyone gets stiffer joints with aging, diabetes accelerates the usual loss of flexibility by changing the structure of collagen in the joints, tendons, and ligaments. In short, glucose “sticking” to joint surfaces and collagen makes people with diabetes more prone to overuse injuries like tendinitis and frozen shoulder (1; 2). It may also take longer for their joint injuries to heal properly, especially if blood glucose levels are not managed effectively. What’s more, having reduced motion around joints increases the likelihood of injuries, falls, and self-imposed physical inactivity due to fear of falling.

Reduced flexibility limits movement around joints, increases the likelihood of orthopedic injuries, and presents a greater risk of joint-related problems often associated with diabetes, such as diabetic frozen shoulder, tendinitis, trigger finger, and carpal tunnel syndrome. These joint issues can come on with no warning and for no apparent reason, even if an individual exercises regularly and moderately, and they may recur more easily as well (3). It is not always just due to diabetes, though, since older adults without diabetes experience inflamed joints more readily than when they were younger.

So what can you do to keep your joints mobile if you’re aging (as we all are) and have diabetes? Regular stretching to keep full motion around joints can help prevent some of these problems, and also include specific resistance exercises that strengthen the muscles surrounding affected joints. Vary activities to stress joints differently each day. Overuse injuries occur following excessive use the same joints and muscle in a similar way over an extended period of weeks or months, or they can result from doing too much too soon.

Doing moderate aerobic activity that is weight-bearing (like walking) will actually improve arthritis pain in hips and knees (4). People can also try non-weight-bearing activities, such as aquatic activities that allow joints to be moved more fluidly. Swimming and aquatic classes (like water aerobics) in either shallow or deep water are both appropriate and challenging activities to improve joint mobility, overall strength, and aerobic fitness. Walking in a pool (with or without a flotation belt around the waist), recumbent stationary cycling, upper-body exercises, seated aerobic workouts, and resistance activities will give you additional options to try.

Finally, managing blood glucose levels effectively is also important to limit changed to collagen structures related to hyperglycemia. Losing excess weight and keeping body weight lower will decrease the risk for excessive stress on joints that can lead to lower body joint osteoarthritis (5). Simply staying as active as possible is also critical to allowing your joints to age well, but remember to rest inflamed joints properly to give them a chance to heal properly. You may have to try some new activities as you age to work around your joint limitations, but a side benefit is that you may find some of them to be enjoyable!

References:

  1. Abate M, Schiavone C, Pelotti P, Salini V: Limited joint mobility in diabetes and ageing: Recent advances in pathogenesis and therapy. Int J Immunopathol Pharmacol 2011;23:997-1003
  2. Ranger TA, Wong AM, Cook JL, Gaida JE: Is there an association between tendinopathy and diabetes mellitus? A systematic review with meta-analysis. Br J Sports Med 2015;
  3. Rozental TD, Zurakowski D, Blazar PE: Trigger finger: Prognostic indicators of recurrence following corticosteroid injection. J Bone Joint Surg Am 2008;90:1665-1672
  4. Rogers LQ, Macera CA, Hootman JM, Ainsworth BE, Blairi SN: The association between joint stress from physical activity and self-reported osteoarthritis: An analysis of the Cooper Clinic data. Osteoarthritis Cartilage 2002;10:617-622
  5. Magrans-Courtney T, Wilborn C, Rasmussen C, Ferreira M, Greenwood L, Campbell B, Kerksick CM, Nassar E, Li R, Iosia M, Cooke M, Dugan K, Willoughby D, Soliah L, Kreider RB: Effects of diet type and supplementation of glucosamine, chondroitin, and msm on body composition, functional status, and markers of health in women with knee osteoarthritis initiating a resistance-based exercise and weight loss program. J Int Soc Sports Nutr 2011;8:8

How to Improve What Really Matters: Quality of Life, Not Longevity

Active senior swimmerFor many years, I have focused on aspects of lifestyle and health management that can enhance quality of life, especially when living with diabetes, rather than simply on living a long time (longevity). Much of my motivation is derived from watching my maternal grandmother suffer through six (long) years of severe disability related to cardiovascular complications of diabetes starting at the age of 70 that left her unable to feed herself or communicate, bed bound, and with almost no quality of life for her final six years. Really, what is the point of simply being alive in that case? This topic has come up again recently. New research published online ahead of print in Diabetologia in Spring 2016 (1) presented results showing that the life expectancy and disability-free life expectancy at age 50 years were 30.2 years and 12.7 good years, respectively, for men with diabetes, and 33.9 years and 13.1 good years for women with diabetes.

Really think about what those estimates mean: If you’re female and have diabetes at age 50, you would be expected to live almost to age 84, but likely be disabled in some way from the age of 71 forward. If the disability is severe (as in the case of my stroked-out grandmother), then that is a lot of pointless years of being alive without really living, not to mention being a huge burden to your family.

Admittedly, that’s pretty discouraging. The best solution may be to focus on what we can do to prevent disability with aging rather than simply living longer. Here are three proven ways to improve your quality of life with diabetes (and likely your longevity):

Exercise regularly and be more physically active overall. Even if you already have some diabetes health issues like peripheral neuropathy, which can negatively impact quality of life, exercising regularly can help. In older adults with diabetes and neuropathy, engaging in just 8 weeks of moderate-intensity aerobic exercise improved their quality of life and led to less pain, more feeling in their feet, less restriction in their activities of daily living, better social interactions, and a greater overall life quality—just after 8 weeks of training (2). Other types of physical activity have similar and profound effects on living well with neuropathy (3), so choose what you enjoy doing the most and start with those.

Eat more fiber, found abundantly naturally in plant-based foods. We all know we should be eating more fiber, but where can you find it (besides in Metamucil, which may not have the same health benefits)? Look for it in plant-based foods, mainly fruits, vegetables, grains, beans, and nuts and seeds. Dietary fiber and whole grains contain a unique blend of bioactive components including resistant starches, vitamins, minerals, phytochemicals, and antioxidants, all of which are critical to healthy living. A higher fiber intake helps prevent or protect against health issues that can decrease both quality of life and longevity, including constipation, hemorrhoids, colon cancer, gastric reflux, obesity, diabetes, stroke, and cardiovascular diseases (4). It also keeps the healthful gut bacteria in your digestive tract more abundant, which directly can benefit health and even prevent obesity. Aim for as much as 50 grams of fiber in your daily diet for optimal health.

Improve the quality and quantity of your sleep. Both sleeping better and sleeping enough (7 to 8 hours a night for most adults) lower insulin resistance and can help improve diabetes control; alternately, not getting enough good sleep can make your blood glucose levels much harder to manage. As you age, it may require taking a melatonin supplement to help you fall asleep and improve diabetes control (5), but exercising regularly certainly assists as well, so try taking your daily dose of exercise to optimize sleep. Get started on these three easy changes today to improve your chances for living longer without disabilities. Remember, there’s more to life than living a long time. What’s the point of living longer if you can’t live well and feel your best every day of your life? It really is your choice to make because you can affect the outcome.

References cited:

  1. Huo L, et al. “Burden of diabetes in Australia: life expectancy and disability-free life expectancy in adults with diabetes” Diabetologia 2016; DOI: 10.1007/s00125-016-3948-x. 2. Dixit S, Maiya A, Shastry B: Effect of aerobic exercise on quality of life in population with diabetic peripheral neuropathy in type 2 diabetes: a single blind, randomized controlled trial. Quality of Life Research 2014;23:1629-1640
  2. Streckmann F, Zopf EM, Lehmann HC, May K, Rizza J, Zimmer P, Gollhofer A, Bloch W, Baumann FT: Exercise intervention studies in patients with peripheral neuropathy: a systematic review. Sports Med 2014;44:1289-1304
  3. Otles S, Ozgoz S: Health effects of dietary fiber. Acta Scientiarum Polonorum Technologia Alimentaria 2014;13:191-202
  4. Grieco CR, Colberg SR, Somma CT, Thompson A, Vinik AI: Melatonin supplementation lowers oxidative stress and improves glycemic control in type 2 diabetes. International Journal of Diabetes Research, 2(3): 45-49, 2013 (doi: 10.5923/j.diabetes.20130203.02)

How to Be the Biggest Maintainer, Not Just the Biggest Loser

Biggest maintainer

A study in Obesity in May 2016 (1) reported very discouraging findings for a group of participants who had lost weight on “The Biggest Loser” (TBL) reality TV show: not only did almost all of them regain a significant amount of weight over the 6-year period afterwards, but they also had lower resting metabolic rates than expected for their body weights, even six years later. With media spin, it won’t be a surprise if everyone just gives up staying thinner and blames excess weight on a faulty, and unchangeable, metabolism.

However, there are a number of factors that impact body weight and weight regain after loss, not just resting metabolism. How much physical activity people do daily and what type, the types of food that people eat, how many calories they actually ingest daily and when they consume them, stress management, and sleep patterns also have an impact on weight maintenance and regain after loss, among other things.

My issues with this study and with TBL’s approach to weight loss are the following:

(1) The way the contestants go about losing large amounts of body weight in a relatively short time is not sustainable as a lifestyle to maintain body weight after loss;

(2) Although TBL participants exercise (a whole lot) during their initial, six-month weight loss period—which helps prevent even greater losses of lean body mass than they would experience otherwise with such extreme weight loss—it does not prevent all muscle mass loss, which means that their total amount of muscle decreased (regardless of their relative ratios of fat and non-fat tissues);

(3) Dietary changes are as important to weight management as they are to weight loss, and diet is de-emphasized on TBL, with a focus instead on reality-TV- and entertainment-driven crazy amounts and types of physical activity; and

(4) TBL approach is not the same as that reported by successful losers and maintainers followed in the National Weight Control Registry (http://www.nwcr.ws).

With regard to that last point, much can be learned from studying members of the National Weight Control Registry (NWCR), which only includes people with medically documented weight losses of at least 30 pounds that were maintained for at least a year. While the members lost and keep the weight off in a variety of ways, most report continuing to maintain a low-calorie, low-fat diet and doing high levels of physical activity. Among the NWCR members: 78% eat breakfast every day; 75% weigh themselves at least once a week; 62% watch less than 10 hours of TV per week; and 90% exercise, on average, about 1 hour per day.

In one study, NWCR subjects spent significantly more time per day in sustained bouts of moderate-to-vigorous physical activity than their overweight counterparts (41.5 ± 35.1 min/day vs. 19.2 ± 18.6 min/day) and marginally more than normal weight adults (25.8 ± 23.4), so they were actually getting more daily exercise than most (2). A 10-year study of self-reported weight loss and behavior change in 2,886 NWCR participants (78% female; mean age 48 years), and more than 87% were still maintaining at least a 10% weight loss after five and ten years (3). Even though decreases in leisure-time physical activity, dietary restraint, and frequency of self-weighing, along with increases in percentage of energy intake from fat and disinhibition, were associated with greater weight regain, the majority of weight lost by NWCR members has been maintained over 10 years.

Others have reported that the differences in total weight gain in people being overfed similar amounts of calories was likely due to the total amount of daily movement that they engaged in, including standing, fidgeting, and taking more steps, not just planned exercise (4). Weight maintenance may, therefore, as influenced by total daily activity that is not necessarily reported or measured like most moderate and vigorous exercise is.

Weight maintenance may also be as simple as staying on top of body weight. NWCR studies have shown that consistent self-weighing may help individuals maintain their successful weight loss by allowing them to catch weight gains before they escalate and make behavior changes to prevent additional weight gain, and decreased self-weighing frequency is independently associated with greater weight regain (5).

Clearly, the body is a complex system with many different bodily and environmental factors adding to the mix. In the TBL study, there was no indication that they controlled for the potential effects of the last bout of exercise on resting metabolic measures (at least this was not reported on in the study), although exercise can impact metabolism for 2-72 hours afterwards They did not measure or report on the types of foods that the “biggest losers” were eating, although fiber is known to improve the gut microbiota and may be related to successful weight loss and maintenance (7). While many reported being active, doing cardio training versus resistance can have differing impacts on muscle glycogen storage, muscle mass, and insulin action, as well as resting metabolism, and the type of activity done was not reported in TBL study.

So, before we jump to any conclusions and blame all weight regain on something completely outside our control (a lower resting metabolism) and relinquish all personal responsibility for weight maintenance, make sure to consider all of the other potentially confounding variables that have not necessarily been well studied at this point. Let’s not just rely on and sensationalize the results of one small pilot study of “biggest losers,’ but rather take away lessons learned from the successful maintainers who are members of the much more reality-based NWCR.

Reference cited:

  1. Fothergill E, Guo J, Howard L, Kerns JC, Knuth ND, Brychta R, Chen KY, Skarulis MC, Walter M, Walter PJ, Hall KD: Persistent metabolic adaptation 6 years after “the biggest loser” competition. Obesity 2016:n/a-n/a